Research
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Enzybiotics are a novel class of antibacterials, based on the peptidoglycan lysins, which kill rapidly and specifically the bacteria, preventing the appearance of crossed resistances with other pathogens and the microbiota degradation.
Read more: The CW_7 repeats of enzybiotics target the bacterial peptidoglycan
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Pathogens try to escape from our immune system by mutating their proteins. To prevent the bacterium from infecting the cells with a single mutation, the NAIP5 protein of the inflammosome is capable of detecting bacterial flagellin at several sites.
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The notion that strong laser light can intervene and modify the dynamical processes of matter has been demonstrated and exploited both in gas and condensed phases.
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The i-motif is four-stranded DNA structure stabilized by hemiprotonated cytosine base pairs (C:C+). Although this is a very attractive structural motif for the development of devices at a nanometric scale, the requirement of acidic pH for its formation makes the i-motif occurrence in vivo controversial.
Read more: Prevalent sequences in the human genome can form i-motif structures at physiological pH
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Statistics from structural genomics initiatives reveal that around 50-55% of the expressed, non-membrane proteins cannot be purified and therefore structurally characterized due to solubility problems
