Research
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- Category: Research
The study identifies a LD-transpeptidase from Gluconobacter oxydans, LDTGo, capable of generating 1,3 cross-links in the peptidoglycan. A high-resolution structure has been determined, revealing distinctive features.
Read more: A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks
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These structures are not forgotten due to lack of interest but rather because they are difficult to study. Until now, there has been only one published structure of an antiparallel triplex, and that was 30 years ago.
Read more: The Antiparallel Triplex: Rediscovering Overlooked DNA Structures
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Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage φ29
Read more: Flexible structural arrangement of the DNA-binding protein p6 from Bacillus phage φ29
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We provide the first experimental analysis of AGT structural dynamics, showing that stability is heterogeneous in the native state and providing a blueprint for frustrated regions with potentially functional relevance.
Read more: Insights into the pathogenesis of PH1 from the structural dynamics of AGT enzyme variants
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Biochemical, biophysical and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.
Read more: The calcium sensor NCS-1 keeps the the Gα chaperone and GEF Ric-8A under tight control
