Seminario impartido por Marina Serna, del CNIO
Microtubules are highly dynamic structures whose continuous assembly and disassembly cycles serve important cellular roles. While microtubules are spontaneously disassembled in the so-called catastrophe events, microtubule de novo assembly is meticulously regulated in both time and space. A multi-subunit complex embedded into the pericentriolar material of the centrosome, called g-Tubulin Ring Complex (gTuRC), orchestrates these assembly events and ensures the proper formation and orientation of the mitotic spindle during cell division. Our research is focused on understanding the molecular mechanism and regulatory basis of the gTuRC complex. This involves a comprehensive analysis of high-resolution cryo-electron microscopy structures, providing insights into the intricate working of this important protein complex.
Fecha del seminario: 11/09/2024 12:00
Lugar del seminario: salón de actos IQF
Ponente del seminario: Marina Serna
