AMPA Glutamate receptors (AMPARs) are ion channels located at postsynaptic membranes, where they bind Glutamate, the main excitatory neurotransmitter in the central nervous system.
AMPA Glutamate receptors (AMPARs) are ion channels located at postsynaptic membranes, where they bind Glutamate, the main excitatory neurotransmitter in the central nervous system. In the brain, the four AMPAR subunits (called GluA1 to GluA4) predominantly form GluA2-containing heterotetrameric receptors, which are calcium impermeable. AMPAR heterotetramers also interact with auxiliary proteins, such as Transmembrane AMPAR Regulatory Proteins (TARPs) and cornichon, which modulate receptor trafficking properties, pharmacology, conductance and channel kinetics. Different neuronal populations, glial cells or even neuron regions express different populations of AMPAR complexes, which are also developmentally regulated. As AMPARs are drug targets for the treatment of neurological diseases, it is key to understand the unique architecture and function of different AMPAR complexes. Here I will summarize the recent advances in the structural biology of AMPAR complexes, focusing on the gating cycle of the GluA1/2-TARP-8 complex. I will describe the structural features of the receptor in different functional states and dissect the impact of TARP-8 in the modulation of the channel properties.
Fecha del seminario: 26/01/2022 12:00
Lugar del seminario: Salón de Actos
Ponente del seminario: Beatriz Herguedas
