Building and shaping tissues and organs relies on the ability of cells to efficiently pack together and regulate their interactions.
Building and shaping tissues and organs relies on the ability of cells to efficiently pack together and regulate their interactions. In this context, we recently showed that epithelial cells display a previously undescribed geometrical shape when tissues are subjected to bending (curvature): the scutoid. This discovery has opened the door to a deeper understanding of morphogenesis. Yet, the consequences of this new paradigm in terms of the 3D cellular organization remains largely uncharacterized. In this talk I’ll discuss how we have addressed this problem using a combination of experiments, mathematical analyses, computer simulations, and biophysical approaches. In that context I’ll show that the thickness and curvature of epithelial tissues are linked to the cellular connectivity via energetic cues. This principle explains how the topological and physical constraints inherent to living matter contribute to build functional complex shapes and lead to the self-organization of tissues.
Fecha del seminario: 09/02/2022 12:00
Lugar del seminario: Salón de Actos
Ponente del seminario: Javier Buceta
