Seminario impartido por Teresa Giráldez, Catedrática de Fisiología en la Universidad de La Laguna/Instituto de Tecnologías Biomédicas
Large conductance Ca2+- and voltage-gated K+ channels (BK, hslo or KCa1.1) are high conductance potassium channels that are synergistically regulated by voltage and intracellular calcium. In many physiological contexts, BK channels are located in close proximity to calcium sources, coupling calcium signalling to membrane potential. These functional associations are generally known as calcium nanodomains. The interaction between calcium influx and BK activation is involved in numerous processes such as repolarization and hyperpolarization following the action potential, dendritic calcium spikes, neurotransmitter release, synaptic transmission and plasticity. In this talk, I will present recent studies investigating the biophysical mechanisms underlying BK gating and their molecular interactions with voltage-gated calcium channels or N-methyl-D-aspartate receptors (NMDAR). If time permits, I will also present our efforts to use the acquired knowledge to generate novel BK-based calcium sensors to study the function of neuronal Ca-nanodomains.
Fecha del seminario: 13/12/2023 12:00
Lugar del seminario: salón de actos IQF
